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Breast Cancer Ribbon Tattoos
Its incidence is in rise in the developing countries, may be due to the life style changes. Breast Cancer Ribbon TattoosThis cancer, the most accessible cancer; has generated much interest in the recent past in understanding its process of development, the genetics and developing more effective treatment modalities. The surgery has evolved from maximum dissection to minimal and more conservative approach. Newer chemotherapeutic drugs are coming up as well as more precision radiotherapy. Approach to breast cancer has become essentially multidisciplinary in the last decade or two. Here we will search literature to add more knowledge to our existing views on this cancer. The views expressed in it may not be conclusive, may be in a trial phase and does not anyway supersede the opinion of treating doctor of a patient.
Notch pathway in cell division and its inhibitors: The primitive cells during development of baby and also later in life are capable of differentiating to one or other cell types. This recruitment of daughter cells and their multiplication is largely controlled by what is called a Notch pathway. These primitive cells are called the stem cells; can form e.g. bone cell, muscle cell and heart cell etc. This notch pathway is also responsible for regulated tissue growth i.e. no excess or no less; through communication between the cells. It can be likened to cells having sensors on their outer membrane, represented by notch a protein. The communication may be something like this: one cell will say to its neighbor cell; “Hi, I am dividing to muscle cell; you need not go in that line”, “Oh yeah, you carry on; I am going in the line of breast cells”, would be the reply. Again to have controlled growth close contact between the cells is required. The Notch would be keeping close contact between cells, may be in a way something like this;”Hello my dear neighbor come closer and closer, do not go away.”
Any derangement in this notch may give rise to uncontrolled growth of cells. In cancer, there are stem cells which divide continuously to give rise to a visible tumor. These stem cells are resistant to conventional chemotherapy and could be the cause of recurrence of cancer, at least in some 1% of breast cancers; which also makes a large number. So the Notch inhibitors can be instrumental in controlling some cases of breast cancer recurrence, when used in addition to chemotherapy. “The Notch pathway regulates self-renewal of stem cells and research indicates that it also regulates cancer stem cell self-renewal, the impact of using a Notch inhibitor was to sensitize a significant proportion of otherwise treatment-resistant cancer stem cells. This supports the notion that a select sub-population of cells in breast cancer is largely responsible for disease recurrence and cancer spread.” I quote from a study’s lead author, Jenny Chang, M.D., professor of medicine at Baylor College of Medicine. She and her team implanted mice with human breast cancer biopsy material that included breast cancer stem cells, and then gave them a Notch inhibitor (MRK-003) or a placebo. MRK-003 significantly reduced formation of clusters of tumor cells called mammospheres, when compared with placebo.
Role of spices like turmeric and piperine: As Reported by HealthDay News, 2009 December 11, breast stem cells appear to be sensitive to certain spices. When researchers at the University of Michigan Comprehensive Cancer Center applied curcumin and piperine to breast cancer cells, they noted that the number of stem cells (but not normal cells) decreased. Curcumin is a component of turmeric, and piperine is found in black pepper. Both of these dietary compounds have been studied previously for their effects against cancer, but this is the first study to evaluate their effects on stem cells.
Alcohol and cancer: Even a few glasses of wine or cocktails a week may increase the risk of recurrence for breast cancer survivors, researchers found. Women who averaged three to four or more drinks per week were 34% more likely to have a recurrence, than those who drank less than once a week; according to an observational study led by Marilyn L. Kwan, PhD, of Kaiser Permanente in Oakland, Calif. Likewise, breast cancer-specific mortality risk rose to 51% for the regular drinkers among breast cancer survivors; Kwan’s group reported at the San Antonio Breast Cancer Symposium. After a breast cancer diagnosis, women who drink alcohol should consider cutting back, they recommended.
Amplification of fibroblast growth factor receptor-1 in breast cancer: Shiang CY, Qi Y, Wang B, Lazar V, Wang J, Fraser Symmans W, Hortobagyi GN, Andre F, Pusztai L., Department of Breast Medical Oncology, USA, studied that: fibroblast growth factor receptor-1 (FGFR-1) is amplified in 10% of human breast cancers. A FGFR-1 small molecule inhibitor may have direct anti-proliferative effects in addition to its’ anti-angiogenic effects. According to Kristjansdottir K, Dizon D.Warren Alpert Medical School of Brown University, USA, a human epidermal growth factor (EGF) receptor (HER)-dimerization inhibitor that represent a novel class of agents, aimed at blocking HER2 from pairing with other receptors of the HER family, may play a role in the management of HER2-positive breast cancers. Trastuzumab is one of the drugs of this group.
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Effect of osteoporosis inhibitor drugs on breast cancer: Researchers from the University of Pittsburgh Cancer Institute, led by Brufsky, concluded that zoledronic acid, a bisphosphonate, is safe and effective for use by postmenopausal women with breast cancer; who are being treated with aromatase inhibitors. Bone mineral density increased 6.2 percent in women taking zoledronic acid, compared with 2.4 percent in the control group. Fractures were also reduced slightly in the treatment group. It may be effective in inhibiting spread of the disease to bone.
Vitamin D and cancer: Researchers say that vitamin D in high doses may have a beneficial effect in preventing breast cancer. High-dose vitamin D significantly reduced muscle and joint pain in breast cancer patients treated with the aromatase inhibitor like anastrozole. Weekly vitamin D supplementation led to significant improvement in pain and mobility after two months, said Antonella Rastelli, MD, of Washington University at the San Antonio Breast Cancer Symposium.
Breast cancer genetic evolution decoded: In the metastatic cancer, 32 protein-altering mutations were found that were not present in healthy tissue from the same woman, according to Samuel Aparicio, BM BCh, PhD, MRCPath, of the British Columbia Cancer Agency, and colleagues. Then, using the same approach, they looked back at cancer tissue taken from the same woman during treatment nine years earlier to see which variants were present then. Five variants, in the genes ABCB11, HAUS3, SLC24A4, SNX4, and PALB2 were common in the DNA of the primary tumor. They had previously been unknown to researchers. Another six in the genes KIF1C, USP28, MYH8, MORC1, KIAA1468, and RNASEH2A were found in between 1% and 13% of the primary tumor cells. There were 19 that were not detected and two were undetermined, the researchers said. This shows that genetic mutation takes place in the course of the disease.
Regular exercise reduces cancer risk: Regular moderate-to-vigorous exercise may reduce breast cancer risk for postmenopausal women, researchers found. Postmenopausal women who maintained more than seven hours per week of higher intensity activity over the 10-year period prior to entry into the study, were 16% less likely to develop breast cancer (RR 0.84, 95% CI 0.76 to 0.93), according to Tricia M. Peters, M.Phil, and colleagues of the National Cancer Institute. It may be that some cancer genes are switched off in exercising population. The same effect has also been seen in case of colon cancer, published in a recent article.
Ginseng appears to help breast cancer patients: The traditional Chinese herb ginseng may improve survival and enhance the quality of life of breast cancer patients, an observational study suggested. Compared with those who never used ginseng, breast cancer patients in China who took it regularly before their diagnosis had a disease specific mortality that was 30% lower, three to four years later; said Xiao-Ou Shu, M.D., Ph.D., and colleagues, of the Vanderbilt-Ingram Cancer Center, published online by the American Journal of Epidemiology.
Breast density and cancer risk: All post-menopausal women should be screened for breast cancer risk by assessing breast density combined with other risk factors, researchers say. They found that breast density was strongly associated with breast cancer. To reduce breast cancer risk overall, they advised, physicians should recommend exercise, weight reduction, a low-fat diet, and reduced alcohol intake. But they also noted that eating fruits and vegetables was not associated with a decreased risk. Still, the researchers concluded that breast density combined with other risk factors is a viable assessment of risk.
Breast feeding and cancer: Breast feeding can significantly reduce the risk of breast cancer, according to a study by Cancer Research UK. The increase in the disease in developed countries is due to women having fewer children and breast feeding for shorter periods of time, the study says.
Metformin under evaluation for cancer treatment: The glucose-lowering drug metformin, used as first line drug in obese type 2 diabetes is showing anticancer activity, reported by “The Lancet”. There has been possible association between obesity and different cancers. It may be possible in future to know more about action of metformin. The data come from the studies being conducted in both the diabetes and oncology research communities, according to experts who spoke at the annual meeting of the European Association for the Study of Diabetes.
Soy safe for breast cancer survivors: Soy consumption appears to be safe, and potentially even protective, for women with breast cancer despite fears about estrogen-like effects, according to a population-based study by the researchers. Benefits of soy appeared to increase with intake up to 11 g of soy protein or 40 mgs. of soy isoflavone per day.
Lymphatic chemotherapy: Platinum based drugs used in chemotherapy have many side effects. Researchers have found out that lymphatic route of administration of these drugs may be less toxic than vascular route. When these and some other chemotherapeutic agents are administered subcutaneously gets better concentrated in the lymphatic tissue, which is the most common path of spread of cancerous cells to other organs from the primary.
hormone receptor status: The estrogen receptor(ER) status has much predictive value, and tissue expressing ER in patients of post menopausal status are more likely to be benefited from its inhibitor drugs like tamoxifen.
High precision Radiotherapy: Radiotherapy has become an integral part of multidisciplinary approach to breast cancer treatment. It has undergone tremendous modification to cause least possible damage to the surrounding tissue through delivery of high precision radiotherapy.
Surgery related changes: Surgery has changed from maximum tissue removal to minimal tissue removal and more conservative in approach i.e. from radical mastectomy to lumpectomy or quadrantectomy. Intra-operative frozen section biopsy to determine disease free margin in the tissue to be left with, has facilitated conservation of breast; so also, an intra-operative radiation detecting probe that detects radiation from the cancerous tissue, pre-injected with radio-active substances that accumulates specifically in the cancerous cells. Breast reconstruction has become very attractive option in the recent days adding confidence to the working cancer survivors.
Investigations: Fine needle aspiration cytology FNAC), ultrasound (USG), mammogram, magnetic resonance imaging (MRI), computerized tomography (CT) and positron emission tomography (PET) are some of the armors in the hands of health care personnel, to boost their ability for early diagnosis; and thereby providing effective treatment.
Carcinoma gene expression and prediction of breast cancer: Breast cancer (BRCA) suppressor gene is responsible for error free repair of Genetic material during cell division. Faulty BRCA may be responsible for breast cancer. According to estimates of lifetime risk, about 12.0 percent of women (120 out of 1,000) in the general population will develop breast cancer sometime during their lives compared with about 60 percent of women (600 out of 1,000) who have inherited a harmful mutation in BRCA1 or BRCA2. In other words, a woman who has inherited a harmful mutation in BRCA1 or BRCA2 is about five times more likely to develop breast cancer than a woman who does not have such a mutation. Breast cancer patients may additionally be tested for carcinoma antigen (CA-125).
We hope to conquer this cancer in the near future, probably more through a genetic manipulation and life style change.
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Banned: Bracelets for Breast Cancer
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Cuisinart CPB-300 SmartPower 15-Piece Compact Portable Blending/Chopping System Meet the Cuisinart SmartPower Compact Portable Blender – the compact powerhouse that does it all! Use the streamline blending cup to make smoothies in a flash! Mince herbs in the chopper cup and whip up custom drinks right in the “To-Go” cups – we’ve included four of them so everyone can have their favorite! Designed of fit anywhere, the Compact Portable Blender delivers big blender performance wi… |
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The Promise $4.56 IL DIVO THE PROMISE… |
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Greatest Hits: The Road Less Traveled $4.68 17 tracks. Small drill hole into barcode…. |
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Girls Night [VHS] $8.75 … |
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Exposure: Environmental Links to Breast Cancer [VHS] $7.90 Narrated by Olivia Newton-John, Exposure unwinds like 60 Minutes “lite”–the goods are in there somewhere, but the production isn’t quite sure how to package them. It works best as a beginner’s guide to environmental dangers that may be boosting breast cancer rates: radiation, toxic chemicals, and therapeutic drugs. The scientific and medical experts, nearly all women, do an excellent job making … |
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Yoga for Breast Cancer $9.95 … |
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Apollo Precision Tools DT9706P 39-Piece Pink General Tool Set $20.96 The Apollo Precision Tools 39-piece pink tool set comes with attractive pink accents and helps fund breast cancer awareness initiatives. It is heat treated and chrome plated to resist corrosion. It is securely housed in a handy blow-molded case. All the tools meet or exceed ANSI critical standards. It contains the tools needed for most small repairs around the house…. |
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Breast Cancer Awareness Scarf $26.99 Show your support while keeping warm this winter with this Breast Cancer Awareness scarfFashion accessory is crafted of the coziest cashmere blend Ideal for men or women, scarf is available in black color option |
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Farouk CHI Pink Breast Cancer Awareness 1-inch Flat Iron (Refurbished) $62.04 Sport sleek hair while supporting a cause with this breast cancer awareness hair curling ironHair care device made of rubber and ceramic |
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Geneva Platinum Women’s Rhinestone Breast Cancer Awareness Watch $23.99 This stylish watch features a pink breast cancer awareness ribbon with a coordinating silicone band. The sparkling Czech rhinestones and luminescent hands add sparkle and detail, completing the look of this finely crafted timepiece. |
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Sterling Silver Diamond Breast Cancer Awareness Necklace $69.99 Crafted of sterling silver, this necklace features a diamond-accented ‘Breast Cancer Awareness’ ribbon design. A satin finish completes the look of this beautiful necklace. |
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Polished Breast Cancer Awareness Pink Crystal Necklace $19.49 Beautifully designed breast cancer awareness ribbon pendant with ruby stone crystals on silver tone snake chain. |
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Breast Cancer Awareness Scarves (Set of 3) $31.99 Add style to your wardrobe with a set of chiffon scarvesSet of three scarves features Breast Cancer Awareness motifsEach scarf in the set features the pink ribbon associated with breast cancer awareness |
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Breast Cancer Awareness Scarves (Set of 2) $23.99 Add style to your wardrobe with a set of chiffon scarvesSet of two scarves features Breast Cancer Awareness motifsEach scarf in the set features the pink ribbon associated with breast cancer awareness |
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Breast Cancer Awareness Designer Bangle Bracelet $19.99 Show your support with a breast cancer awareness designer bangle braceletBeautiful designer bracelet has four sides with the words ‘Together We can make a Difference’Jewelry features two sides with five (5) pink hearts |
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Sterling Silver Breast Cancer Awareness Ribbon Charm $23.49 Charm features a breast cancer awareness ribbon design painted in pink enamelJewelry is crafted of fine sterling silverCharm features a jump ring that is easily applied to your favorite chain or bracelet |
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Medline Foldable Rollator for Breast Cancer Awareness $103.49 Foldable Pink rollator supports breast cancer awareness4-wheeled walker made with lightweight aluminum frameTool free and easy to assemblePadded seat and back rest |
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Silvertone Breast Cancer Awareness Ribbon Beads (Pack of 2) $10.79 These silvertone two-sided beads feature breast cancer awareness ribbons with rope-edge detail. These beads fit your Pandora-style bracelet and Biagi, Chamilia, and Troll chains. |
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Breast Cancer Awareness Carry All Tote Bag $20.79 Carry your cause and your valuables in this Breast Cancer awareness carry all tote bagThis carry all bag has been dedicated to cause women’s healthTote features a single pocket on the outside of bag |
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Stainless Steel Pink Crystal Breast Cancer Awareness Bracelet $12.99 Show your support for breast cancer awareness with this beautiful stainless steel and pink crystal bead bracelet. With an antiqued finish and simple toggle clasp, the ribbon charm on this bracelet stands out for unique style and a meaningful message. |
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Breast Cancer Awareness Pencil Tub (Case of 96) $42.99 Brand: PrangPencil counter displayPackage contains one (1) pencil counter display of 96 Breast Cancer Awareness pencils |
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Silvertone Breast Cancer Awareness Badge Holder Neclace $13.29 Beautiful Breast Cancer Awareness necklace featuring a pink ribbon pendant charm and pink charms placed along the chain. This necklace is not only a great wearable piece, but practical as an eyeglass or conference badge holder. |
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Silvertone Breast Cancer Awareness Ribbon Large Hole Beads (Pack of 2) $11.39 These silvertone two-sided beads feature a pink enamel design with breast cancer awareness ribbons. These beads fit your Pandora-style bracelet and Biagi, Chamilia, and Troll chains. |
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14k Gold Diamond Breast Cancer Ribbon Disc Pendant $205.99 Let your fashion accessories speak for you with this Breast Cancer Awareness Ribbon pendant necklaceJewelry piece is designed in 14-karat rose gold Stylish Breast Cancer Awareness Ribbon disc pendant contains 17 round cut diamond accents |
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Pink Goldplated Sterling Silver Breast Cancer Ribbon Charm $20.99 Show off your support of breast cancer research with a pink ribbon charmSilver charm features a classic overlapping pink ribbon designJewelry is crafted of pink goldplated sterling silver |
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Breast Cancer Hand-woven Coir Doormat 18′ x 30′ $22.99 Show your support for a very important cause with this Breast Cancer Support Coir Doormat. Featuring a durable handmade construction, this doormat will continue to promote support for several seasons. |
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Breast Cancer Awareness Pink 18-oz Water Bottle $13.29 Size: 8.75 inches high x 2.75 inches in diameterThis 18-ounce water bottle is made from Eastmen Tritan Copolyester A portion of the proceeds will be donated to Breast Cancer Awareness |
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Symphony Designs Breast Cancer Awareness Pashmina Shawl (Set of 2) $29.49 Show your support for breast cancer awareness with a chic pink scarf from Symphony Designs. Fringed ends highlight this set of fashionable wraps. |
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Silvertone Pink Crystal Breast Cancer Awareness Ribbon Charm Necklace $14.39 Light-reflecting pink crystals adorn this small Breast Cancer Awareness ribbon charm pendant. The necklace is crafted of silvertone base metal and fastens with a lobster claw clasp. |
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Stainless Steel Pink Crystal Breast Cancer Awareness Bracelet $12.99 Show off this beautiful silvertone and pink bracelet in honor of breast cancer awareness. Adorned with pink crystals, ribbon charms and ‘hope’ beads, this meaningful bracelet lets you show your support for an important cause with incredible style. |
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Stainless Steel Pink Crystal Heart Breast Cancer Awareness Bracelet $12.99 This beautiful bracelet features highly polished stainless steel and light pink crystal beads strung on an elastic wristband. With pink heart and polished ribbon charms, this bracelet shows your support for breast cancer awareness with elegance. |
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La Preciosa Sterling Silver Cubic Zirconia Breast Cancer Ribbon Necklace $30.99 This breast cancer ribbon pendant by La Preciosa shines with 17 round-cut cubic zirconia. This jewelry piece is made of sterling silver and features an 18-inch chain with a spring ring clasp. |
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14k Gold and Silver Diamond Accent Breast Cancer Awareness Necklace $67.99 This stunning pendant features a breast cancer awareness ribbon set in round-cut diamonds. This necklace is made of sterling silver and 14-karat gold and features an 18-inch cable chain. |
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Silvertone Clear Crystal Breast Cancer Awareness Ribbon Charm Necklace $14.69 This light-reflecting silvertone breast cancer awareness charm necklace showcases stunning clear crystals. This beautiful necklace features a silvertone chain with an extender for adjustable fitting. |
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BAM Women’s Crystal Breast Cancer Awareness Pink Ribbon Hat $39.99 This Pink Breast Cancer Awareness Ribbon BAM Hat is Hand Painted and adorned with Genuine Swarovski Crystals. The hat is adjustable in the back with a Velcro closure and a loop for a pony tail. |
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Sterling Silver/ 14k Gold Diamond Breast Cancer Awareness Necklace $68.99 Crafted of sterling silver and 14-karat yellow gold, this necklace features a diamond-engraved ‘Breast Cancer Awareness’ ribbon design. A highly polished finish completes the look of this beautiful necklace. |
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Charming Life Silvertone Jade and Quartz Breast Cancer Awareness Bracelet $31.99 This elegant bracelet showcases a pink enamel awareness ribbon hanging from a strand of pink rose quartz, pink jade, glass, Swarovski crystals, and stylized pewter beads. Bracelet features a lightly antiqued pewter toggle. |
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Breast Cancer 3-piece Terry Cloth Cosmetic Bags $15.99 Think pink with this set of terry cloth cosmetic bagsConvenient and cute, these bags give all your toiletries a homeEach bag features an easy clean lining, trim details and zip top closure |
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Jiffy Esteam Hand-held Pink Travel Steamer $64.49 Jiffy Steamer’s ‘Breast Cancer Awareness’ steamer is available in pinkEsteam is the most powerful hand-held steamer on the market |
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14k Gold 1/10ct TDW Diamond Breast Cancer Awareness Ribbon Necklace $212.49 Shimmering pendant features a glistening diamond awareness ribbon on a smooth discJewelry is crafted of rosy 14-karat pink goldDiamond ribbon necklace is an excellent way express your support of a good cause |
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Set of 10 Lokta Paper Pink Polka Dots Note Cards (Nepal) $7.59 Color/design options: Pink polka dotMaterials: Lokta paperBlank inside |
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14k Gold 1/10ct TDW Diamond Breast Cancer Awareness Ribbon Necklace $205.99 Shimmering pendant features a glistening diamond awareness ribbon on a smooth discJewelry is crafted of luscious 14-karat yellow goldDiamond ribbon necklace is an excellent way express your support of a good cause |
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Bleek2Sheek True Hope Collection: Pink Edition Charm Bracelet $20.99 This beautiful and versatile charm bracelet is stunning with an array of pink beads and charms which are centered around breast cancer awareness. This bracelet can be personalized with interchangeable beads and charms as wanted. |
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Cuisinart DCC-1100PK 12-Cup Pink Programmable Coffeemaker $71.99 Cuisinart created its Pink Series to help support breast cancer research. A portion of proceeds from the sale of every Cuisinart Pink Series product will be donated to this cause. |
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Pink Ribbon Enchantment Fresh Floral Bouquet $59.99 Floral bouquet helps fight breast cancerProFlowers is proud to partner with Susan G. Komen to offer Pink Ribbon Enchantment mixed bouquetFresh and vibrant pink Gerbera daisies and pink aster flowers are ideal for someone special |
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Wilson Hope Women’s White Pearl Golf Balls (Pack of 60) $62.99 Wilson makes a donation to the Breast Cancer Research Foundation with every purchase of the Hope golf balls. These golf balls are pearl white and sold as a set of five dozen. |
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Wilson Hope Women’s Pink and Purple Golf Balls (Pack of 60) $62.99 Wilson makes a donation to the Breast Cancer Research Foundation with every purchase of the Hope golf balls. These pink and purple golf balls are sold as a set of five dozen. |
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CHI Air Breast Cancer Awareness Combo Pack 1 set $99.99 |
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Medline Pink Breast Cancer Awareness Rollator Walker $108.00 |
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